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In Studies JMEN, PARAMOUNT, and JMEI, where all patients received vitamin supplementation, incidence of Grade 3 to 4 neutropenia ranged from 3% to 5%, and incidence of Grade 3 to 4 anemia ranged from 3% to 5%

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Giving them more frequently than the established schedule is a form of over-treatment that is not supported by evidence and can strain healthcare resources (nurses’ time, clinic space, and medication supplies)